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KMID : 0363320180390061136
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Journal of Korean Oriental Internal Medicine
2018 Volume.39 No. 6 p.1136 ~ p.1149
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The Effect of Opae-san for Peptic Ulcer Disease: A Systematic Review and Meta-Analysis
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Lee Yu-Ri
Cho Na-Kyung
Kim Kyung-Soon
Choi Hong-Sik
Kim Seung-Mo
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Abstract
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Objectives: The aim of this study was to perform a meta analysis of randomized controlled trials (RCTs) that applied Opae-san to pepticulcer.
Methods: The databases NDSL, RISS, KISS, KISTI, Oasis, DBpia, Cochrane, EMBASE, Pubmed, and CNKI were searched to identify RCTs that evaluated the therapeutic response to Opae-san on peptic ulcer. The selected studies were assessed using Cochrane Group's risk of bias tool.
Results: 12 RCTs were selected from a total of 312 identified. Combined therapies of Opae-san plus triple therapy were superior to only triple therapy in achieving the effective rate (risk ratio=1.26, 95% CI: 1.17 to 1.35, p<0.001, I2=0%), the helicobacter pylori eradication rate (risk ratio=1.23, 95% CI: 1.12 to 1.34, p<0.001, I2=7%) and the recurrence rate (risk ratio=0.31, 95% CI: 0.12 to 0.82, p=0.02, I2=0%). But only Opae-san was not superior in achieving the effective rate compared to anti gastric secretion drugs.
Conclusions: The current evidence suggests that combined therapies of Opae-san plus triple therapy yield a higher effective rate, and helicobacter pylori eradication rate and a lower recurrence rate. However, in most of these studies, it is difficult to evaluate the bias and therefore better designed studies are needed.
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KEYWORD
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pepticulcer, Opae-san, Korean medicine, systematic review, meta-analysis
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